Living Longer

Human aging is being controlled and researchers have proven that human cells can be created and in this century people will begin to live 100, 200 or even 300 years. Mice are already living 50% longer with the help of genetic inventions. Thanks to the human genome project, scientists are closer to identifying ways to decelerate human aging. Contrarily, with incompetent, insufficient, and laughable healthcare system in place, Pakistan seems to continue grappling with policy lapses. Due to factors related to high fertility rates, high illiteracy, high mortality, and above all uncreative methods of policy planning, Pakistan stands as a stranger to such a milieu. Its policymakers don’t even sense the world passing through a profound transformation. They lack their understanding for making decisions to understand forthcoming breakthroughs and strategically plan for new environs.

The rapid pace of technology and medicine are quickly posing the prospect of banishing aging and disease, and yes even most causes of death. Some of the most extreme but very possible aspects of technologies such as molecular manufacturing and nanomedicine promise continual cellular maintenance that will alleviate aging altogether and make it impossible for disease or toxins to injure one's body or take one's life. Present anti-aging treatments do not slow aging and do not extend life span more than quitting smoking, exercising, eating vegetables, or heeding ordinary medical advice does. While all over the world we have seen improvements in health and life spans, Pakistan has large gaps and much effort needs to be spent in narrowing that gap.

Although vainly wrestling with high female mortality at younger ages and during the reproductive years, Pakistan claims a life span of 65. This predominantly seems farce when almost one-half of women receive no antenatal care during their pregnancy and 72 percent receive no postnatal care at all.

The advancements in longevity can be generally attributed to improvements in sanitation, the discovery of antibiotics, and medical care. Despite tall claims, Pakistan’s record on these areas is hopeless. Now, as scientists make headway against chronic diseases like cancer and heart disease to extend anti-aging even further, such diseases in Pakistan are greater than ever and basic healthcare service is inaccessible to a vast majority.

There are theories on aging. The programmed theories hold that aging follows a biological timetable, perhaps a continuation of the one that regulates childhood growth and development. The damage or error theories emphasize environmental assaults to our systems that gradually cause things to go wrong.

Lengthening life expectancies in the industrialized nations are bringing about substantial changes including large increases in the number of elderly and in their proportion in the population. Such changes have occurred, for example, in the type of economic activity, housing, social services, and population make-up of the communities. With growth in the health care system and changes in the service mix provided, the elderly continue to consume more health care per capita and need different services.

Health care institutions, including hospitals, which are widely expected to experience increasing demand as the elderly population grows; organizations will provide home-based medical care and other types of assistance, allowing the individual to remain in their own residence; and a variety of assisted living facilities, ranging from adult day care to residential care to nursing homes.

Of greater concern, the already awful health care industry of Pakistan finds itself ill prepared to handle significant increases in the number of the very elderly. Today, there are almost 9.7 million senior citizens. When it has no policy in place for this population today, it has no concern for tomorrow. Neither public nor private sectors are equipped financially to deal with the problems caused by aging population. When a society starts aging, its economic vitality becomes inferior to that of young societies and sluggish economic growth reduces its opportunities to become well heeled. Thus, in Pakistan an aging population will become a heavy public burden, forcing its people to bring down the cost by establishing large institutions so that, by virtue of economies of scale, they could manage to provide the elderly with the most basic care and medical needs.

The health sector of Pakistan offers an inadequate remedy for the serious problems of an outdated and basically unsound system and hence needs an offensive. People must be offered a vision of a revitalized health care system that provides incentives for increased quality and technological innovation, while at the same time, reducing costs. Pakistanis need a system that gives them control over healthcare decisions, while encouraging them to set aside the resources they need to purchase this care.

The policy makers of Pakistan should keep themselves abreast of technological advances and management strategies by constantly scanning the literature and media, interviewing authorities, and drawing on other sources to identify emerging trends. These trends then need to be analyzed to select those that are most significant.

It needs to begin to prepare now for what will be a very different future. The key questions it needs to think about include: What is it that we should be asking? What is it that its policymakers need but do not get in their human development courses? People should be asking about connections -- connections between existing mindsets and human development. These connections simply are not made in most textbooks available for use in human development courses. In fact, effective change requires more than knowledge of human development. Effective change also requires the ability to devise strategies that take advantage of that knowledge … strategies for connecting research and practice. Asif J. Mir, Organizational Transformation

GM Food

New technologies play an increasing role in food production, and genetically modified foods (GMF) are at the forefront of the changing nature of our food culture. The promise of GMFs seems almost too good to be true. With a human population of more 6 billion, producing higher yielding foods may be more crucial than ever. Genetically modified (GM) crops are now grown in more than 16 countries. In 2002, farmers around the world planted 60 million hectares of land with dozens of varieties of GM crops. The appearance of GMFs in the marketplace of the West has resulted in a firestorm of public debate, scientific discussion, and media coverage. A variety of ecological and human health concerns come with the new advances made possible by GM.

GM is the technique of changing or inserting genes. Genes carry the instructions for all the characteristics that an organism – a living thing – inherits. They are made up of DNA. GM is done either by altering DNA or by introducing genetic material from one organism into another, which can be either a different variety of the same or a different species. For example, genes can be introduced from one plant to another plant, from a plant to an animal, or from an animal to a plant. Transferring genes between plants and animals is a particular area of controversy. Developing countries have special interests, but fairer trade rules would do more to eliminate hunger than GM crops.

GM foods offer a way to quickly improve crop characteristics such as yield, pest resistance, or herbicide tolerance, often to a degree not possible with traditional methods. Further, GM crops can be manipulated to produce completely artificial substances, from the precursors to plastics to consumable vaccines.

By manipulating the genetic code of organisms that provide food sources, they have created new strains of plants and animals capable of growing larger in less time on less suitable soil. From an ecological perspective, adding more food to a starving population promotes reproduction, exacerbating the very condition scientists are trying to solve.

The policymakers of Pakistan ought to see how GM technology can help produce more food and offer medical, social and economic benefits but without attached threats. Some of the many health advantages of GMF include the edible vaccines, which can help curb various diseases in Pakistan. Nutritionally improved crops with a higher content of proteins and vitamins can supplement the nutritional requirements of the lower strata of the population, who cannot afford a non-vegetarian diet. Pulses constitute a major source of protein in Pakistan. However, the presence of raffinose-like sugars can cause digestive problems. The genetically tailored pulses that contain reduced amounts of raffinose and similar sugars can result in enhanced digestibility. GMF that contain sweet proteins like thaumatin will be good for people with diabetes. And GMFs that have greater iron content can be especially beneficial for Pakistani women, as they are susceptible to anemia.

GM crops can result in enhanced agricultural productivity with lower inputs in terms of plant protection strategies and fertilizer applications, raise the per capita income and, hence, the living standard. Further, the availability of better quality nutrition at affordable costs can also improve the general health of the population, which in turn will raise national productivity.

Contrary to the natty payback, many leading scientists admit that GM is unpredictable, unstable, and potentially dangerous because of the consequences. GMF raises the possibility of human health, environmental, and economic problems, including unanticipated allergic responses to novel substances in foods, the spread of pest resistance or herbicide tolerance to wild plants, inadvertent toxicity to benign wildlife, and increasing control of agriculture by biotechnology corporations.
In Pakistan it will be a tragedy if the multinational corporations pushing genetically engineered crops gain control over crops and seeds. Although the corporations claim biotechnology is needed to feed the world, this is a myth. There is already more than enough food to feed everyone; poverty and inadequate allocation of resources are the major hurdles. According to a FAO report, the world can produce enough food to meet global demand in the year 2030 without the use of GM crops.
Meanwhile, organic farmers are among those most threatened by GMF. One reason is because cultivation of genetically engineered crops on neighboring farms can contaminate their crops via pollen drift. No genetically engineered materials should be used in organic products. Thus, a grower may be unable to sell his or her crop as organic if it has been contaminated
Ultimately, it is the consumer--and all Earth's inhabitants--who have the most to lose in the long run. Because little thought is being given to the consequences of what GM crops will do to the environment and to biodiversity, Earth's ecosystem could be turned upside down. There will be no way to undo the damage or recall new organisms that have been unleashed.
Large seed companies are likely to make large profits from GM crop seeds. This will be exacerbated if they make crops that produce sterile seeds, which cannot be replanted the following year. Consumers and small farmers who are forced to buy seed year after year will lose.
Pakistan needs to adopt a harmonized, uniform and transparent procedure for safety assessment of GMF. Coordinated and comprehensive labeling requirements for GMF should also be prepared with the aim of providing the consumer with a real choice.
Pakistan has a national food poverty rate of 33% and 40% of children under the age of five are underweight, 50% are stunted, and 9% are wasted. The GMF has the capability of overcoming these problems. Its dubious impact, nevertheless, compels us to seriously consider all pros and cons before the risks involved in GMF take the nation by surprise. Asif J. Mir, Organizational Transformation

Talking about Genomics

Molecular biology has long held out the promise of transforming medicine from a matter of serendipity to a rational pursuit grounded in a fundamental understanding of the mechanisms of life. Molecular biology has begun to infiltrate the practice of medicine; genomics will hasten the advance. Within 50 years, we expect comprehensive genomics-based health care to be the norm. We will understand the molecular foundation of diseases, be able to prevent them in many cases and design accurate, individualized therapies for illnesses.

In the next decade, genetic tests will routinely predict individual susceptibility to disease. When the genome is completely open to us, such studies will reveal the roles of genes that individually contribute weakly to diseases but interact with other genes and with environmental influences, like diet, infection and prenatal exposures to affect health.

By 2010 to 2020, gene therapy should also become a common treatment, at least for a small set of conditions. Within 20 years, novel drugs will be available that derive from a detailed molecular understanding of common illnesses like diabetes and high blood pressure. The drugs will be designer therapies that target molecules logically and are therefore potent without significant side effects. Drugs like those for cancer will routinely be matched to a patient’s likely response, as predicted by molecular fingerprinting. Diagnoses of many conditions will be much more thorough and specific than now. For example, a patient who learns that he has high cholesterol will also know which genes are responsible, what effect the high cholesterol is likely to have, and what diet and pharmacologic measures will work best for him.

By 2050, many potential diseases will be cured at the molecular level before they arise, though large inequities worldwide in access to these advances will continue to stir tensions. When people become sick, gene therapies and drug therapies will home in on individual genes, as they exist in individual people, making for precise and customized medical treatment. The average life span will reach 90 to 95 years, and a detailed understanding of human aging genes will spur efforts to expand the maximum span of human life.

In Future, the complete DNA sequencing of more and more organisms, including humans, will revolutionize biology and medicine. It is predicted that genomics will answer many important questions, such as how organisms evolved, whether synthetic life will ever be possible, and how to treat a wide range of medical disorders.

If, within a few years, scientists can expect to amass a tidy directory of the gene products—RNA as well as proteins—essential for life, they may well be able to make a new organism from scratch by stringing DNA bases together into an invented genome coding for invented products. If this invented genome crafts a cell around itself and the cell reproduces reliably, the exercise would be the ultimate proof that we understand the basic mechanisms of life.

In the last 50 years, a single gene or a single protein often dominated a biologist’s research. In the next 50 years, researchers will shift to studying integrated functions among many genes, the web of interactions among gene pathways, and how outside influences affect the whole system.

Within 50 years, with all genes identified and all possible cellular interactions and reactions charted, pharmacologists are developing a drug or toxicologists trying to predict whether a substance is poisonous may well turn to computer models of cells to answer their questions.

Being able to model a single cell will be impressive, but to fully understand the life forms we are most familiar with, we’ll plainly have to consider additional levels of complexity. We will have to consider how genes and their products behave in place and time—that is, in different parts of the body and in a body that changes over a lifespan.

So far, developmental biologists have striven to find signals that are universally important in establishing an animal's body plan, the arrangement of its limbs and organs. In time, they will also describe the variations—in gene sequence, perhaps in gene regulation—that generate the striking diversity of forms among different species. By comparing species, we’ll learn how genetic circuits have been modified to carry out distinct programs, so that almost equivalent networks of genes fashion, for example, small furry legs in mice and arms with opposable digits in humans.

In 50 years, we will fill in many details about the history of life, though we may still not understand how the first self-replicating organism came about; we will learn when and how – by inventing, adopting, or adapting genes – various lineages acquired, for example, new sets of biochemical reactions and different body plans. The gene-based perspective of life will have taken hold so deeply among scientists that the basic unit they consider will likely no longer be an organism or a species, but a gene. They will chart which genes have traveled together for how long in which genomes.

Scientists will also address the question that has dogged people since Darwin’s day: What makes us human? What distinguishes us as a species? Undoubtedly, many other questions will arise over the next 50 years. As in any fertile scientific field, the data will fuel new hypotheses. Paradoxically, as it grows in importance, genomics may not even be a common concept in 50 years, as it radiates into many other fields and ultimately becomes absorbed as part of the infrastructure of all biomedicine.

Genetic information and technology will afford great opportunities to improve health and alleviate suffering. But any powerful technology comes with risks, and the more powerful the technology, the greater the risks. In the case of genetics, people of ill will today use genetic arguments to try to justify bigoted views about different racial and ethnic groups. How we will come to terms with the explosion of genetic information remains an open question. Asif J. Mir, Organizational Transformation