Talking about Genomics

Molecular biology has long held out the promise of transforming medicine from a matter of serendipity to a rational pursuit grounded in a fundamental understanding of the mechanisms of life. Molecular biology has begun to infiltrate the practice of medicine; genomics will hasten the advance. Within 50 years, we expect comprehensive genomics-based health care to be the norm. We will understand the molecular foundation of diseases, be able to prevent them in many cases and design accurate, individualized therapies for illnesses.

In the next decade, genetic tests will routinely predict individual susceptibility to disease. When the genome is completely open to us, such studies will reveal the roles of genes that individually contribute weakly to diseases but interact with other genes and with environmental influences, like diet, infection and prenatal exposures to affect health.

By 2010 to 2020, gene therapy should also become a common treatment, at least for a small set of conditions. Within 20 years, novel drugs will be available that derive from a detailed molecular understanding of common illnesses like diabetes and high blood pressure. The drugs will be designer therapies that target molecules logically and are therefore potent without significant side effects. Drugs like those for cancer will routinely be matched to a patient’s likely response, as predicted by molecular fingerprinting. Diagnoses of many conditions will be much more thorough and specific than now. For example, a patient who learns that he has high cholesterol will also know which genes are responsible, what effect the high cholesterol is likely to have, and what diet and pharmacologic measures will work best for him.

By 2050, many potential diseases will be cured at the molecular level before they arise, though large inequities worldwide in access to these advances will continue to stir tensions. When people become sick, gene therapies and drug therapies will home in on individual genes, as they exist in individual people, making for precise and customized medical treatment. The average life span will reach 90 to 95 years, and a detailed understanding of human aging genes will spur efforts to expand the maximum span of human life.

In Future, the complete DNA sequencing of more and more organisms, including humans, will revolutionize biology and medicine. It is predicted that genomics will answer many important questions, such as how organisms evolved, whether synthetic life will ever be possible, and how to treat a wide range of medical disorders.

If, within a few years, scientists can expect to amass a tidy directory of the gene products—RNA as well as proteins—essential for life, they may well be able to make a new organism from scratch by stringing DNA bases together into an invented genome coding for invented products. If this invented genome crafts a cell around itself and the cell reproduces reliably, the exercise would be the ultimate proof that we understand the basic mechanisms of life.

In the last 50 years, a single gene or a single protein often dominated a biologist’s research. In the next 50 years, researchers will shift to studying integrated functions among many genes, the web of interactions among gene pathways, and how outside influences affect the whole system.

Within 50 years, with all genes identified and all possible cellular interactions and reactions charted, pharmacologists are developing a drug or toxicologists trying to predict whether a substance is poisonous may well turn to computer models of cells to answer their questions.

Being able to model a single cell will be impressive, but to fully understand the life forms we are most familiar with, we’ll plainly have to consider additional levels of complexity. We will have to consider how genes and their products behave in place and time—that is, in different parts of the body and in a body that changes over a lifespan.

So far, developmental biologists have striven to find signals that are universally important in establishing an animal's body plan, the arrangement of its limbs and organs. In time, they will also describe the variations—in gene sequence, perhaps in gene regulation—that generate the striking diversity of forms among different species. By comparing species, we’ll learn how genetic circuits have been modified to carry out distinct programs, so that almost equivalent networks of genes fashion, for example, small furry legs in mice and arms with opposable digits in humans.

In 50 years, we will fill in many details about the history of life, though we may still not understand how the first self-replicating organism came about; we will learn when and how – by inventing, adopting, or adapting genes – various lineages acquired, for example, new sets of biochemical reactions and different body plans. The gene-based perspective of life will have taken hold so deeply among scientists that the basic unit they consider will likely no longer be an organism or a species, but a gene. They will chart which genes have traveled together for how long in which genomes.

Scientists will also address the question that has dogged people since Darwin’s day: What makes us human? What distinguishes us as a species? Undoubtedly, many other questions will arise over the next 50 years. As in any fertile scientific field, the data will fuel new hypotheses. Paradoxically, as it grows in importance, genomics may not even be a common concept in 50 years, as it radiates into many other fields and ultimately becomes absorbed as part of the infrastructure of all biomedicine.

Genetic information and technology will afford great opportunities to improve health and alleviate suffering. But any powerful technology comes with risks, and the more powerful the technology, the greater the risks. In the case of genetics, people of ill will today use genetic arguments to try to justify bigoted views about different racial and ethnic groups. How we will come to terms with the explosion of genetic information remains an open question. Asif J. Mir, Organizational Transformation

Film Production in coming days

In a world of flickering screens, large and small, filmmakers will work inside and outside of the studios and television networks, bring in diverse voices to televisions, cinemas, and computers alike, tell stories ruled not by profit but by art, by conviction, and by people’s need to connect to one another and the world around them. In the same world ignoramus filmmakers of Pakistan—clueless about the modern technologies, the art and science of filmmaking together with the oddments of globalization—will drag on poking holes in technological jumps and thus demonstrating that they were powerless to draw breath in the 21st Century.

Future’s digital technology will transform the way the media is made and consumed. The moment is not far off when critical decisions will be made, in the halls of government and in the marketplace, about how digital technology will be used to create, copy, distribute, and present media in the years to come.

As digital opportunities and challenges change our landscape, one question will stand out: how will the public—and the diversity that filmmakers bring to it—benefit? Filmmakers will depend on a healthy public media ecosystem, and our shared future tied to policy that nurture or weaken that system. They will take creative risks, speak their minds, and champion the many voices that matter most but seldom heard.

For future’s media makers, the essence of digital is this: everything we do to create content can be turned into a series of ones and zeros that our naked eyes can’t decode into pictures and sounds, but that a variety of devices can.

This new digital code will change media making forever. This code will transform the four most important processes for media makers—production, replication, distribution, and presentation.

To produce media, future’s artist will be able to point a digital video camera at a tall mustachioed man scratching his ear and capture this moving image, represented inside the camera as a unique piece of digital code. The artist will manipulate that code to remove the man’s mustache and add a large and hungry dinosaur bearing down behind him (using CGI technology). The artist will then combine this new code with other pieces of code to shape a complex story of images, sound and music (using editing systems such as Avid or Final Cut Pro).

The result will be an enormous sequence of finished code: a movie, say, that will be copied an unlimited number of times, with each copy an exact replica of the original. Any of these copies will then be transmitted through the air, across wires or via a physical container (such as a CD), depending on how large the code is and how much capacity the transmitter has read at the receiving end in many different ways by a wide variety of devices—a computer, a projector, a television, a phone—that translate the code into images and sound.

The possibilities with digital technology will be nearly infinite. The realities will be much more confined. The question with digital will not be what might happen, but what filmmakers actually do with it.

The dizzying pace of digital change will, in fact, catch us all somewhat by surprise. Businesses and lawmakers will scramble to catch up with the changes wrought by this technological explosion. New business models and new policies will be built to deal with it.

Major economic stakeholders in tomorrow’s burgeoning media economy will all work hard to shape the outcome in their own interests. And much will be at stake for them all, because digital technology will challenge the traditional business models that media companies have relied on to profit financially from their work.

But they will not be the only stakeholders. There will also be public—all of us as citizens and parents and children, artists and consumers. When the dust will settle on the new digital economy and society, how will the public have benefited? Will the media policies actually promote freedom of speech and diversity of expression? Will they foster the many facets of the cultures that make up a nation?

The good news is that digital technology will make production cheaper, faster, and more manageable. It will also open up avenues for distribution, such as the Internet and, to a lesser extent, cable and satellite, while drastically reducing the costs of replicating copies of an filmmaker’s work.

And that’s also the bad news. Filmmakers will face challenges in three big areas: ownership, distribution, and funding. Specifically: (1) Ownership: How will filmmakers protect their work from unauthorized use and copying, while still having access to others’ work for legitimate use in their own creations? (2) Distribution: Will new distribution networks give filmmakers more or less access to audiences—and how will that distribution affect production? (3) Public support: How will the public resources now provided—such as spectrum allotments and public funding—change in the digital era?

In the days and age of democracy, stakeholders will assert their interests in the coming changes. Broadcasters, movie studios, technology companies, and other players will try to figure out how to make sure that the answers to these questions benefit them. They will take their issues to legislators, to the courts, and to consumers. The result will be policy.

Filmmakers will also be stakeholders—as well as artists and business people with a job to do. Digitization won’t change everything. The old standbys of good storytelling, the battles over concentrated ownership, the resistance to change by those with power, and conflicts over public support will repeat themselves in the digital age.

Digital will change the ecosystem that the filmmakers live in. The vision that filmmakers bring will be important, as stakeholders thrash out the terms under which they use digital code. Cut and dried, this future has already made an entrance in Hollywood. Asif J. Mir, Organizational Transformation

Up and coming Fashion

Fashion is really just starting to interact with the world of information technology (IT). Today there are already ‘cool’ gadgets and wearables, but in future, we will see whole new domains where fashion can play a key role. The biggest of these is the duality of appearance - where we may appear one way in the physical world, and have a whole range of digital appearances in the augmented reality and virtual environment worlds. This will lead to many people designing for themselves.

Along the way, electronics will continue to shrink in size to a point where it no longer significantly need affect the form of the object that carries it. Form and function will be separated at least as far IT is concerned.

Fashion is often at the forefront of technology usage. Many new materials and technologies are used in textiles and accessories when they are still too expensive or primitive for other uses. Technology development is accelerating quickly and shows no sign of slowing down in the foreseeable future, so fashion designers will have a lot of fun over the coming years. The next decades will see the gradual convergence of nanotechnology, biotechnology, information technology and cognitive technologies. Typical results will be materials with different tensile, thermal and optical properties, integration of IT into fabrics, and linkage of our bodies to the network for medical and communication purposes, via clothing or skin-wearables.

Thin, flexible displays are becoming available already, and we will undoubtedly see them built into clothing with increasing frequency. This will be both for body adornment and functional uses.

A wide range of electronic devices can already be built into clothes and this will increase. New fabrics are already being developed to provide power generation - using solar power, electromagnetic, thermal and mechanical means.

Storage technology is improving extremely quickly and we may expect massive amounts of storage to be available in very small volumes, so that people can take all their files, music and videos with them - integrated invisibly into small devices or clothes.

Haptics technology (the technology of enabling the remote sensation of touch) will also become available as part of clothes. A variety of electro-responsive materials exists already, albeit sometimes in primitive forms (for example, muscles wires, polymer muscles, shape memory alloys, etc), and these will progress quickly into routine fabric technologies.

Clothes will be part of the ambient intelligent environment we will inhabit in a few years’ time. There will be myriads of chips all around us - in building infrastructure, furniture, gadgets, clothes, foods, packaging, even on our skin and inside some peoples’ bodies (for medical and security purposes).

Chips in the environment or on our person will offer processing, storage, sensing identity and communications. The resulting smart environment will know who we are, what we are doing, where we are, to the nearest few millimeters, and all about us, subject only to our own preferences and privacy or security laws.

Chips will be physically very small, so have it in their power to be hidden anywhere, and any functionality that won’t physically fit into a device can be accessed via the smart environment. This means that fashion designers can add a wide range of functions to something without needing to change its design.

Various sensors on and about our person will monitor our behaviors and physical characteristics, and respond accordingly. One of the areas that computers may want to go in with other people’s digital bubbles is that of personality characteristics. An ego badge would alert us to other people that are likely to be of interest to us so that our social and sex lives would improve. A related device is the active contact lens, which uses tiny lasers and micro-mirrors built into a contact lens with circuitry and power supply, to raster scan a high resolution image onto our retinas. This is called direct retinal projection.

Any computer generated images could be superimposed on what we see in the real world. We would be able to modify how we see other people so when you meet people you could change how they look. Come hell or high water, beauty will quite literally inhere in the eye of the beholder.

We will not be limited by the properties of physical materials, or have to have the same appearance for everyone looking at us, nor even have the same appearance all day. Our appearance can be different to each viewer and different each time they look at us. So fashion designers will need to design virtual fashions, and these will need to be dynamic and context sensitive. Through and through, dual appearance dictates dual fashion.

One of the accessories that we might need in such a world is the digital ‘aura generator’. This will act as a sort of wireless web server that radiates our digital appearance into the nearby space. It is almost like the hologram generators that science fiction fans will recognize from Red Dwarf. The main difference is that it will make us look different to different people.

With increasing assistance expected from AI in all walks of life, we should expect that people would often want to design their own clothes - making most of the artistic decisions and letting the computer sort out the technical stuff.

As local production becomes more widespread, self-design may become very popular indeed. How much this affects the market for professional fashion designers will thus depend on how much relative skill and creativity they really have, as well as on how much effort people can be bothered to invest in designing themselves.

These developments bring us to the heart of how fashion will change. Such future is near at hand when we will have to worry about both our digital appearance as well as our physical looks. And on that account indeed our digital appearances can be infinitely diverse. Asif J. Mir, Organizational Transformation

English in 21st Century

The future of today’s global language, English, is more complex and less certain. It will retain its excellence in the 21st century and is unlikely to be displaced as the world’s most important language. Its usage is an intricate system in which many factors act together in ways that are not easily foreseeable. Just the same, recent progress in shaping the behavior of complex systems, like weather, could help us understand the patterns that may emerge in the globalization of English.

From north and south and east and west, there are more than 1,400 million people living in countries where English has official status. One out of five of the world’s population speaks English at some level of competence. Demand from the other four fifths is bumping up. English is the main language of books, newspapers, airports and air-traffic control, international business and academic conferences, science technology, diplomacy, sport, international competitions, advertising and pop music.

Almost all those who are professionally associated with the English language worldwide acknowledge that there is no imminent danger to the English language, or to its global attractiveness.

Yet with the emergence of new world order and global transition, the next 20 years or so will be a critical time for the English language and for those who hang upon it. The structures of usage and public attitudes to English will have long-term consequences for its future.

The future of English will be more complex, more demanding of understanding and more challenging for the position of native-speaking countries than has up till now been thought.

The global popularity of English is in no immediate danger, but that it would be unwise to see in the mind’s eye that its predominant position as a world language will not be threatened in some world regions for use as the economic, demographic and political shape of the world as it transforms.

The future of English will however be a complex and plural one. The language will grow in usage and variety; yet simultaneously diminish in relative global importance. To put it in economic terms, the size of the global market for the English language may increase in absolute terms, but its market share will probably decline.

Additional reasons that have resulted the reduced fervor threaten trends of increased usage of English. The growing adoption of English as a second language, where it takes on local forms, is leading to disintegration and multiplicity. No longer will be the case, if it ever was, that English unifies all who speak it.

The future is going to be a bilingual one, in which a growing ratio of the world’s population will be eloquent speakers of more than one language. There is little to help us understand what will happen to English when the majority of the people and institutions who use it do so as a second language.

Native speakers may feel that the language belongs to them, but it will actually be those who speak English as a second language or foreign language who will determine its world future—the fact that 19th century futurologists failed to foresee that the growth in second and foreign language speakers would be a much more important phenomenon.

As the number of people using English grows, second language speakers will be drawn towards the inner circle of first language speakers and foreign language speakers to the outer circle of second language speakers. All through this status migration, attitudes and needs in respect of the language will change; the English language will diversify and other countries will emerge to compete with the older, native-speaking countries in both the English language-teaching industry and in the global market for cultural resources and intellectual property in English.

The future and globalization symbolizes a significant discontinuity with previous periods. The Internet and related information technologies, for example, may upset the traditional patterns of communication upon which institutional and national cultures have been put together.

In four key sectors, the present dominance of English can be expected to give way to a wider mix of languages: first, the global audio-visual market and especially satellite TV; second, the Internet and computer-based communications including language related and document handling software; third, technology transfer and associated processes in economic globalization; fourth, foreign language learning especially in developing countries where growing regional trade may make other languages of growing economic magnitude.

Computer technology has changed the way people act together both locally and globally. At the present we are at the core of personal and group communications. The Internet will remain the flotilla leader of Global English and it will be a quite different language from what it is today. Nevertheless, there seems to be developing a new, global English-speaking market in the knowledge-intensive industries.

At this point in time there is a significant increase in the numbers of people learning and using English, but a closer examination of driving forces suggests that the long term growth of the learning of English is less secure than it appears to be.

Overtly and covertly, the use of English language is most ubiquitous amongst professional groups and middle class families are most likely to embrace English as the language of the home.

By and by, no single language will occupy the monopolistic position in the 21st century, which English has—almost—achieved by the end of the 20th century. As communications infrastructure ameliorates and relative costs plunge, more telephone conversations around the world will be held in languages other than English.

English must keep up a range of corporate roles and identities and must be usable for both team working and service interactions. Not surprisingly, demands on an employee’s competence in English will rise.

The ELT industry needs to respond to changing international social values—to ensure that the reputation of English language is enhanced rather than diminished. Asif J. Mir, Organizational Transformation

On Cancer

Permit me to embark on this 7-minute journey with Shakespeare’s muse:
Blow, blow, thou winter wind,
Thou art not so unkind
As man's ingratitude.

Mr. President, crusaders, doctors and wonderful audience:
Another British poet and painter William Blake mentioned:

In seedtime learn, in harvest teach, in winter enjoy.

I must appreciate Dr. Phillip rather than poking holes in his selection of wintertime for a forum on a serious public health issue. Perhaps he enjoys wintertime in launching a crusade against the enemy of humankind.

Implicitly and explicitly, under his leadership the team of philanthropists, oncologists, and physicians deserve a thunderous applause on organizing this event with epic cause successfully. Thus and so, we must proffer bouquets on their endeavor for congregating a moot of professionals, researchers and clinical oncologists. Good show, Dr Phillip!

I am privileged for speaking to this wonderful audience not as a guest of honor but being the part of the majestic cause that is behind this Congress.

Ladies and gentlemen, cancer is a killer disease with more than 100 versions. These versions are characterized by excessive, uncontrolled growth of abnormal cells, which invade and destroy other tissues. It develops in almost any organ or tissue of the body, but certain types of cancer are more lethal than others. Cancer is growing cause of death everywhere. For reasons not well understood, cancer rates vary by gender, race, and geographic region. For instance, more males have cancer than females. Cancer rates also vary globally—residents of the United States, for example, are nearly three times as likely to develop cancer than are residents of Pakistan.

Cancer usually develops gradually over many years, the result of a complex mix of environmental, nutritional, behavioral, and hereditary factors. Scientists do not completely understand the causes of cancer, but they know that certain lifestyle choices can dramatically reduce the risk of developing most types of cancer. Not smoking, eating a healthy diet, and exercising moderately for at least 30 minutes each day reduce cancer risk by more than 60 percent.

The Greek physician Hippocrates first made the connection between disease and natural environmental factors in the 4th century BC. His treatise Airs, Waters, and Places described how diseases can result from way of life, climate, impure water, and other environmental factors. For the next 2000 years, it was the most widely used text on public health and epidemiology.

Epidemiologists and other public health officials attempt to break the chain of disease transmission by notifying people who may be at risk for contracting an infectious disease. While the participants may read technical papers, I must emphasize on the need for awareness campaigns for prevention. Behavioral Change Communication must be used in mass awareness.

People need to know that saturated fats from red meats and other animal products are linked with several cancers; high salt intake increases the risk of stomach cancer; adult obesity increases the risk for cancer of the uterus in women and also appears to increase the risk for cancers in the breast, colon, kidney, and gallbladder.

Cancer of the prostate gland is the most cancer among males. People should be made conscious about the need to consult a doctor when they notice unusual health symptoms, such as, changes in bowel or bladder habits, a sore that does not heal, unusual bleeding or discharge, thickening or a lump in the breast or any other part of the body, indigestion or difficulty swallowing, change in appearance of a wart or mole, or a nagging cough or hoarseness.

Scientists estimate that more than 60 percent of cancer deaths are preventable through lifestyle changes.

The society must be educated that lifestyle changes and consumption of such foods that have the potential to protect against cancer. I mean foods comprising broccoli, cauliflower, cabbage, tomatoes, soy products, and foods high in vitamins A, C, and E. In addition, green and possibly black teas contain compounds that protect the body from carcinogens. These foods contain substances called antioxidants that block the action of free radicals. Other chemicals in fruits and vegetables are thought to block the cell growth promoting effects of steroid hormones, protecting against cancers of the breast and prostate.

Mr. President, I would specifically be interested to receive the set of papers, which are likely to be read by experts and scholars in subsequent technical sessions. Apart from filling myself with knowledge, I will use necessary data in dissemination.

I epilogue my statement with a Japanese proverb:
One kind word can warm three winter months.

Permit me to modify this proverb as:
One kind deed can gladden the whole winter and the year round and round.
While wishing success to the crusading spirit of this Congress, I thank you for listening.
May God bless you!
Asif J. Mir,
Organizational Transformation

About Dengue Fever

Dengue Fever, seasonal viral infection characterized by fever, headache, extreme pain in the joints and muscles, and skin rash. A more serious but less common form of the disease, dengue hemorrhagic fever (DHF), may cause severe and fatal internal bleeding. Dengue fever and DHF are caused by any of four different viruses, and are transmitted from one person to another by the female mosquito of two species of the genus Aedes. Outbreaks of the disease usually occur in the summer when the mosquito population is at its peak. The infection cannot be transmitted directly from person to person and not all people who are bitten necessarily contract the disease. Dengue fever and DHF occur in many tropical and sub-tropical areas in Asia, Africa, Central and South America.

The incubation period (time between infection and onset of symptoms) of dengue fever is five to eight days. The fever typically runs its course in six to seven days, but convalescence is usually slow. Treatment for dengue fever is directed at reducing symptoms.

The incubation period of Dengue hemorrhagic is two to seven days. In the early stages the symptoms are very similar to those of dengue fever. The second stage symptoms include nausea, vomiting, and abdominal pain. The onset of hemorrhagic symptoms rapidly follows—bleeding nose and gums, bruising easily, and sometimes internal bleeding. The amount of blood circulating through the body is reduced, sometimes producing shock, characterized by pale, cold extremities; a rapid, weak pulse; and falling blood pressure. Treatment for these symptoms is a standard fluid rehydration therapy in order to maintain blood pressure. If circulatory failure is not reversed, death may follow.

The most effective preventive measure is the use of mosquito repellent. As yet no successful vaccine for dengue fever has been developed. According to the WHO, dengue fever and DHF are among the most rapidly increasing insect-borne illnesses today. Several factors are believed to contribute to the wide spread of dengue fever. Inadequate water and waste treatment facilities, along with insufficient pest control measures, promote the rapid increase of mosquito populations in certain areas. In addition, dwindling public health resources cannot keep up with the needs of growing urban populations that are susceptible to infection.

Complicating matters further are societal changes. Increased international travel accelerates the spread of both new and old diseases: A person infected with an unusual virus on one continent can arrive—with the virus—on another continent in a matter of hours. Ships, planes, and trucks can transport disease-carrying organisms just as easily. In 1985 tires imported into Texas from Asia carried larvae of the Asian tiger mosquito, which is a carrier of dengue fever and other tropical diseases. Within five years, Asian tiger mosquitoes were living in 17 states. The WHO estimates that there are some 50 million cases of dengue infection worldwide every year.

Out and out, the Dengue conundrum has sprung up as a threat to our people and a challenge to health community. It is pouncing on innocent lives it is curable though. This is because our population is unconscious about the source or symptoms. This calls for the need of awareness campaigns. More than treatment, at this moment in time there is a dire necessity to educate people about preventive methods people ought to adopt. Asif J. Mir, Organizational Transformation

Some Stray Thoughts on Pakistan

Each dawn comes but once: It announces another opportunity to right the wrongs and build on the success of yesterday.

Like any other country, the sun rises in the morning in Pakistan. Nevertheless, this sun rises behind the dark thick clouds and its rays do not reach the mother earth where innocent people live, suffer—committing suicides, dumping their lived children or becoming the victims of terrorism, bad governance. It is painfully observed that the national dailies are publishing voluminous editions on non-issues but no column depicts public debate on real problems.

More than two thousand years ago, Diogenes walked down a dusty road in ancient Greece. According to the legend, as he walked, he carried a lighted lantern in his hand. He carried the lantern because even in broad daylight it wasn’t easy to find what he was looking for: an honest man.

Today, after all the passing centuries, in Pakistan one reads the morning newspapers or watches the TV news and wonders if Diogenes would find the search any easier. With so many signs of unethical behavior in the society at large, one may question if ethics have any place.

The absolute increase in population in Pakistan, coupled with such trends as urbanization and greater mobility clearly presents serious threats. If the current population growth rate of Pakistan continued for the next 130 years, its population would be equal to that of the whole world today. Needless to say, this will not happen. Either its birth rate will drop or its death rate will rise. Somehow the growth rate has to stop.

Some foreign industries are growing more competitive than their Pakistani counterparts. For the Pakistan as a nation to be competitive, however, it is not required that all Pakistani companies remain competitive in all areas. It however does mean that Pakistan’s business and entrepreneurs must be able to take advantage of opportunities offered by economic developments in other countries to move into other product lines.

Good infrastructure services are essential to achieve economic growth and improve the quality of life. But for Pakistan, despite improvements in access the quantity and quality of services are well below what is demanded.

The state of education in Pakistan is depressing. Today it simply cannot compete with even third-rate countries in standard indicators of academic achievement. Weak curricula and discipline have guaranteed educational failure for tens of millions of our children. In its most extreme manifestations learning literally has come to a halt. This is not to criticize present or past governments. All the same, the nation should look at itself and conclude that something must be done. It is not, however, that the government should reform education fundamentally. Real reforms come from the people.

The health sector requires offensive for offering an inadequate remedy for the serious problems of an outdated and basically unsound system. People must be offered a vision of a revitalized healthcare system that provides incentives for increased quality and technological innovation. While at the same time, reducing costs and uncertainty. Pakistanis today need a system that gives them control over healthcare decisions, while encouraging them to set aside the resources they need to purchase this care.

The poverty rate in Pakistan is increasing fast. Economic expansion can only nullify this trend. Any welfare policy cannot conquer poverty, nor can government alone. To rid Pakistan of poverty, there must be continued economic growth, deregulation, devolution of power, smaller government, elimination of policies that discourage self-improvement, and a stronger focus on education. The importance of the family in keeping poverty at bay may now be widely accepted, but programs are also needed to strengthen the family.

It is hard for Pakistan to win a successful war on poverty when it is so hard to identify the “enemy.” Even leaving aside such complicated notions as “relative” versus “absolute” poverty, the measurement of poverty is a crude process. The root cause of this defect is that the baseline official poverty rate is badly flawed measurement of what is generally understood to be poverty. It is based on reported cash income. Thus, unreported income is not measured. There has to be consumption standard in place of the income standard, quantity and quality of the food, housing, clothing, and other essential items needed to keep a family just cost of obtaining these items locally would then be the benchmark for determining whether the family’s income was below the poverty level.

Any system of laws that is too complex or expensive for people to understand and use, does not deliver justice. This increasingly has become the case with Pakistan’s legal system. It lacks increased use of mediation, conciliation, mini-trials, and where appropriate, arbitration. Decision makers in Pakistan should think about the dilemma to ensure that access to justice is available to all. Efforts to seek alternatives to litigation throughout the legal system need to be forged.

Terrorists, attacking non-combatant targets in Pakistan, threaten the society today. Their fundamental threat is to innocent citizens, social stability and ultimately, to the legitimacy of the elected regime. The threat from terrorism is growing. Terrorists are being organized, better equipped, and more professional than they were some years ago. Modernity should be used in countering terrorism. Multilateral treaties should also be worked out for effective handling of the threat.

By defining these main items designed to spur Pakistan’s progress, prosperity and competitiveness, the Pakistani intelligentsia can suggest solutions, alternatives, innovative ideas and utilitarian actions to help achieve prosperity. It can recommend means for increasing nation’s ability to sell more overseas through increased productivity. It can imply more efficient production techniques in business through new technology, better methods of industrial organization, cheaper sources of capital goods, or more efficient labor. Through increased productivity standards of living will rise, consumer choice will increase, and more opportunities for well-paying jobs will become available. Similarly, solutions can be recommended to miscellaneous problems that are degenerating the vitals of our national life.

Beyond doubt, the resources of knowledge, experience and expertise if harnessed and suggested means for the revitalization of the dormant energies in all sectors of human endeavor, Pakistan can emerge as a land of opportunities and haven of peace. Asif J. Mir, Organizational Transformation